Search Results - jeffrey+(jeff)+tyner

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Novel single-gene biomarker for acute myeloid leukemia prognosis

Summary The current technology is a novel set of biomarkers derived from the largest ever genomic and transcriptomic data set for acute myeloid leukemia (AML), which includes a novel single gene biomarker capable of strongly predicting AML prognosis. Technology Overview Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with an incidence...

Published: 9/27/2023 | Inventor(s): Daniel Bottomly, Brian Druker, Kara Johnson, Stephen (Steve) Kurtz, Nicola Long, Shannon McWeeney, Anna Reister Schultz, Cristina Tognon, Jeffrey (Jeff) Tyner

Keywords(s): Diagnostics, Diagnostics - Cancer

Category(s): Diagnostics

Effective combinations of targeted agents for hematologic malignancies

Summary Current treatment strategies for acute myeloid leukemia (AML) have low efficacy rates, due in part to the complex and heterogenous underlying genetics of this cancer. Oregon Health & Science University researchers have developed a precision medicine approach for the treatment of AML by identifying an effective combination therapy for a specific...

Published: 9/27/2023 | Inventor(s): Jeffrey (Jeff) Tyner, Elie Traer, Stephen (Steve) Kurtz, Brian Druker, Andrew Kaempf, Christopher (Chris) Eide, Motomi (Tomi) Mori

Keywords(s): Diagnostics, Diagnostics - Cancer

Category(s): Diagnostics

Methods of treating venetoclax-resistant acute myeloid leukemia

SummaryAcute myeloid leukemia (AML) is difficult to treat due to the genetic heterogeneity of the disorder and accompanying drug resistance observed in many patients. Oregon Health & Science University researchers have identified a new therapeutic approach to overcome venetoclax resistance and improve outcomes and prognoses for AML patients experiencing...

Published: 9/19/2023 | Inventor(s): Jeffrey (Jeff) Tyner, Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Shannon McWeeney, Stephen (Steve) Kurtz, Christopher (Chris) Eide, Ravindra Majeti

Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer

Category(s): Diagnostics, Therapeutics

Mutation-specific treatment strategies for acute myeloid leukemia

Summary The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Oregon Health & Science University (OHSU) researchers have identified treatment strategies for a broad scope of AML...

Published: 10/3/2022 | Inventor(s): Jeffrey Tyner, Cristina Tognon, Brian Druker, Daniel Bottomly, Beth Wilmot, Stephen (Steve) Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Shannon McWeeney

Keywords(s): Diagnostics, Diagnostics - Cancer, Therapeutics, Therapeutics - Cancer

Category(s): Therapeutics, Diagnostics