CBP Expression Vector

Case ID:
0536
Web Published:
4/28/2010
Description:

Technology Overview
Cyclic AMP-regulated gene expression frequently involves a DNA element known as the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. This modification stimulates interaction with one or more of the general transcription factors or, alternatively, allows recruitment of a co-activator. CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein).

 

Fusion of a heterologous DNA-binding domain to the amino terminus of CBP enables the chimaeric protein to function as a protein kinase A-regulated transcriptional activator. We propose that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB.

  
Patent Information:
Category(s):
Biological Materials
For Information, Contact:
Trina Voss
Technology Development Manager
Oregon Health & Science University
vosst@ohsu.edu
Inventors:
Richard Goodman
Keywords:
Biological Materials
Biological Materials - Protein/Peptides
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