Summary
Current research methods for measuring protein release rely on quantifying bulk levels in serum and lack the ability to determine temporal and cell-specific release patterns. Oregon Health & Science University researchers have developed a novel technique to allow for visualization and quantification of protein and peptide release in real-time for in vitro and ex vivo applications.
Technology Overview
Accurately measuring protein or peptide release can be difficult due to pulsatile release patterns and low concentrations in serum and cerebral spinal fluid. The laboratory of Carsten Schultz Ph.D. has developed a novel technique to measure protein and peptide release in real-time, increasing the ability to study the regulation of secretory events.
Features of this method include:
This technique could allow for the quantification of stimuli-evoked protein and peptide secretion at a single-cell level with real-time temporal resolution, and could potentially be adapted in future applications to detect hormone secretion in awake freely-moving animals.
Licensing Opportunity
Available for licensing and co-development.