Cell Penetrating Peptides for Drug Delivery

Case ID:
OSU-17-51
Web Published:
3/29/2018
Description:

Technology Description

 

This is a new CPP drug delivery platform based on cell-penetrating self-assembling peptide nanomaterials (CSPNs). Through sequential ligation of peptide building blocks, our researchers created cell-penetrating self-assembling peptide nanomaterials (CSPNs) capable of translocating into cells. Atomic force microscopy revealed that CSPNs form distinct shapes reminiscent of a drill-bit. The fine tuning of CSPN amphiphilic character lends versatile properties such as flexibility, self-assembly, biodegradability, and biocompatibility for effective intracellular delivery. CSPNs self-assemble into “nanodrill-like” structures with a coarse-twisted, non-twisted, or fine-twisted morphology. In particular, the coarse-twisted nanodrills demonstrate high internalization and are capable of in vivo delivery of rapamycin.

 

Features & Benefits

 

  • High capacity to encapsulate hydrophobic guest molecules
  • Demonstrated in vivo delivery
  • Tunable drug delivery platform

 

Applications

 

  • Drug delivery
  • Imaging

 

Background of Invention

 

Cell penetrating peptides (CPPs) are versatile platforms for intracellular delivery of small molecular drugs, liposomes, antibodies, imaging agents, proteins, and nucleic acids. Despite recent advances in the supramolecular assembly of CPP nanostructures, the tuning of size, shape, morphology, and packaging of drugs in these materials remains largely unexplored. Oregon State University is seeking industry collaborators or licensees interested in exploring an exciting new discovery in CPP and drug delivery research.

 

Status

 

Patent Pending

 

Patent Information:
Category(s):
Therapeutics
For Information, Contact:
Joe Christison
IP & Licensing Manager
Oregon State University
541-737-9016
joe.christison@oregonstate.edu
Inventors:
Gaurav Sahay
Ashwani Narayana
Keywords:
CSPN
Drug
Drug Delivery
Peptide
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