This technology is transgenic mouse strain with a targeted mutation of the DNA cross-link repair 1A, PSO2 homolog (Dclre1a) gene displays an increased sensitivity to mitomycin C and may be useful in the study of genomic stability.
This mouse can be found as Jackson Lab Stock # 010524.
Additional information can be foudn at Mol Genet Metab. 2008 May;94(1):38-45.