TUB-4D cell line

Case ID:
1626-B
Web Published:
1/29/2015
Description:

Technology Overview:

Two nucleoside transport-deficient cell lines were developed through isolation from a hypoxanthine-guanine phosphoribosyltransferase-deficient derivative of wild type CEM cells (a human T lymphoblast cell line originally derived from a patient with acute lymphocytic leukemia).  The Ara-C/8C and TUB-4D clones were isolated by virtue of their resistance to 8 µM arabinosylcytosine and 4µM tubercidin, respectively.  One cell line completely deficient in deoxycytidine kinase activity, the Ara-C/8D clone, is a clonal derivative of an hypoxanthine-guanine phosphoribosyltransferase-deficient parent CEM cell line originally isolated in semi-solid agarose containing 8µM arabinosylcytosine.  The Ara-C/8C and TUB-4D cell lines are cross-resistant to a spectrum of cytotoxic nucleosides to which parental and Ara-C/8D cell are sensitive. 

Links/Publications:  Ulllman et al., J Biol Chem. 1988 Sep 5;263(25):12391-6. 

Licensing Opportunity:  The cell lines are available for non-exclusive licensing.

 

Patent Information:
Category(s):
Biological Materials
For Information, Contact:
Trina Voss
Technology Development Manager
Oregon Health & Science University
4-8200
vosst@ohsu.edu
Inventors:
Buddy Ullman
Keywords:
Biological Materials
Biological Materials - Cell Lines
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