Search Results - marcelo+rubinstein

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Transgenic mice expressing a red fluorescent protein in proopiomelanocortin neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs

This technology is a transgenic mouse strain expressing a red fluorescent protein in proopiomelanocortin (POMC) neurons, granule cell neurons of the hippocampal dentate gyrus, pituitary corticotrophs, and pituitary melanotrophs. Jackson Lab Stock #009593.

Published: 9/16/2020 | Inventor(s): Malcolm Low, Veronica Otero-Corchon, Marcelo Rubinstein

Keywords(s): Biological Materials, Biological Materials - Mice

Category(s): Biological Materials, Research Tools

POMC transgenic mice and neuron-specific promoter

Technology OverviewPOMC neurons of the hypothalamus are critical components of the neural circuitry controlling appetite, feeding, and metabolism. In addition they modulate the activity of other hypothalamic neurons which control reproduction, thyroid hormone levels, growth hormone secretion and neuroendocrine stress responses. Genetic evidence in humans...

Published: 9/16/2020 | Inventor(s): Malcolm Low, Marcelo Rubinstein, Flavio Silva De Souza

Keywords(s): Biological Materials, Biological Materials - Mice, Therapeutics, Therapeutics - Neurology

Category(s): Research Tools

D2 Dopamine Receptor Knock-Out Mice

Technology OverviewD2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice, technology #...

Published: 9/16/2020 | Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein, Michele Kelly

Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening

Category(s): Biological Materials

D4 Dopamine Receptor Knock-Out Mice

Technology OverviewResearchers at OHSU have developed technology # 0379, a strain of mice that are genetically deficient in the D4 dopamine receptor. These mice provide a new animal model for the study of the function of the D4 receptor. Homozygous mice may exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine, as well...

Published: 9/16/2020 | Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein

Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening

Category(s): Biological Materials