Comprehensive Diagnostic Classification of Corneal Shape Abnormalities Based on OCT

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Comprehensive Diagnostic Classification of Corneal Shape Abnormalities Based on Optical Coherence Tomography



Distinguishing between different causes of corneal shape abnormalities is critical for optimizing care and surgical recommendations; however, this can difficult to achieve with existing diagnostic measurements. Dr. David Huang’s laboratory has developed a comprehensive diagnostic classification system using topography and OCT imaging that for the first time can differentiate between multiple common causes of corneal shape abnormalities, improving diagnosis, care and surgical recommendations for patients.


Technology Overview

Keratoconus, an eye disease characterized by thinning and bulging of the cornea, is a major contraindication for LASIK surgery, but can be difficult to distinguish from other types of corneal shape abnormalities using current technologies. For example, contact lens-related corneal warpage can result in a similar change in corneal topography, but could resolve with cessation of contact lens wear and is therefore not a permanent contraindication to LASIK. Given most potential LASIK patients wear contact lenses, distinguishing between keratoconus and warpage is challenging and critical. Dr. David Huang et al. have developed a novel comprehensive diagnostic classification system of corneal shape abnormalities by using anterior/posterior topography, pachymetry and epithelial thickness maps, which could all be mapped using a single optical coherence tomography (OCT) scan. These measurements are combined to create novel indices such as the Ectasia Index, the Warpage Index, and the Coincident Thinning Index that for the first time provide an automated way to distinguish between these two conditions to potentially improve diagnosis and care. Utilization of these novel indices found there were able to correctly classify normal (100% specificity), keratoconus eyes (100% sensitivity) and warpage (81% sensitivity) in a study of 72 patients. The indices have potential to classify a wide range of other corneal diseases including dry eye, epithelial basement membrane dystrophy, and irregularities associated with corneal surgeries, scars, stromal dystrophies, and endothelial dystrophies. These two indices can be incorporated into existing OCT software, providing a powerful diagnostic tool to improve pre-refractive surgery work-up and diagnosis of corneal conditions in ophthalmology and optometry clinics.



Tang et al., “Differentiating keratoconus and corneal warpage by analyzing focal change patterns in corneal topography, pachymetry, and epithelial thickness maps.” Invest Opthalmol Vis Sci.  2016; 57:OCT544-OCT549.


Intellectual Property

US patent application 16/547,110, based on provisional patent application filed on June 30, 2016.


Licensing Opportunity

Available for exclusive or non-exclusive licensing

Patent Information:
For Information, Contact:
Arvin Paranjpe
Senior Technology Development Manager
Oregon Health & Science University
(503) 494-8200
Maolong Tang
Yan Li
David Huang
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