Inverse Micelle Preparation for Alginate-Based Drug Delivery Carriers

Case ID:
OSU-18-62
Web Published:
10/31/2018
Description:

 

Technology Description

 

Oregon State University is seeking a licensee or industry collaborator for development and commercialization of a novel method of inverse micelle preparation for alginate-based nanocarriers. The simple process takes only a few hours and can be completed at room temperature, overcoming the challenges common in the field regarding formation difficulties and extensive time requirements. Inverse micelle properties are advantageous because they can encapsulate hydrophilic therapeutics and then be utilized as a drug delivery system. The preparation process includes: adding an aqueous alginate phase containing a hydrophilic therapeutic to a mixture of cyclohexane and dodecylamine, adding cross linking agents to gel the matrix, adding water to contain the nanoparticles in an aqueous layer, and then extracting the layer by pipette. In one example, the inventors encapsulated Doxorubicin (DOX) into the alginate nanocarriers and showed reduced side effects and high effectivity against 4T1 breast cancer cells.

 

Features & Benefits

  • Fast, simple technique for preparation of alginate inverse micelle nanocarriers at room temperature
  • Inverse micelles for encapsulation of hydrophilic therapeutics
  • Encapsulation of DOX for potential breast cancer treatment

 

Applications

 

  • Inverse micelle preparation
  • Drug delivery system for hydrophilic drugs
  • Potential breast cancer treatment

 

Background of Invention

 

Converse to normal micelles, inverse micelles are arranged in organic solvent with their polar heads in and nonpolar tails out. Traditional methods of preparation require relatively high temperatures, at least an entire day, and many involved synthesis steps and reagents. This is a challenge in the field as inverse micelles have unique properties for applications in encapsulation of hydrophilic compounds, such as therapeutics. Alginate is a polysaccharide with inverse micelle capabilities, and its gelation properties allow effective encapsulation of a variety of water soluble molecules. The applications of using alginate nanoparticles in drug delivery are extensive, but a better method of their preparation is needed for highest efficiency and best quality of treatment.

 

Status

 

US patent pending (provisional patent application filed); available for exclusive or nonexclusive licensing

 

 

Patent Information:
For Information, Contact:
Joe Christison
IP & Licensing Manager
Oregon State University
541-737-9016
joe.christison@oregonstate.edu
Inventors:
Conroy Sun
Anna Brown
Justin Rosch
Keywords:
alginate
Drug Delivery
inverse/reverse micelle
micelles
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