Search Results - roger+cone

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Melanocortin-3 Receptor Knockout Mice
Technology OverviewThe central melanocortin system is critical for the long term regulation of energy homeostasis. Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, obesity, and accelerated longitudinal growth in mice and humans. To assess the role of the melanocortin-3 receptor (MC3-R) in energy homeostasis,...
Published: 9/16/2020   |   Inventor(s): Roger Cone, Andrew Butler, Robert Kesterson
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
MC5-R Knockout mice
Technology # 0387-B OverviewMC5-R is responsive to all melanocortins at physiological levels except g-MSH. The melanocortin-5 receptor (MC5-R) is found in a wide range of tissues from skeletal muscle, to adipose tissues, brain, lung, adrenal and stomach. Provided by this invention is a mouse model with a disruption of the MC5-R gene with a severe defect...
Published: 9/16/2020   |   Inventor(s): Roger Cone, Malcolm Low, Wenbiao Chen
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
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