Search Results - david grandy

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Thyronamines: novel bioactive metabolites of thyroid hormone
NOVEL BIOACTIVE METABOLITES OF THYROID HORMONE: A SAFE AND EFFECTIVE TREATMENT FOR DISEASEOHSU Technology 0674Researchers at Oregon Health & Science University and University of California, San Francisco discovered and validated a new class of thyroid hormone metabolites. The most potent of these, 3-iodothyronamine, has been shown in animal stu...
Published: 7/22/2015   |   Inventor(s): Thomas Scanlan, David Grandy, James Bunzow, Katherine Suchland, Matthew Hart, Edwin Tan, Mononori Miyakawa
Keywords(s): Therapeutics, Therapeutics - Cardiology, Therapeutics - Endocrine
Category(s): Therapeutics
D2 Dopamine Receptor and Genes and Associated International Patents
 
Published: 1/29/2015   |   Inventor(s): Olivier Civelli, James Bunzow, David Grandy, Curtis Machida
Keywords(s): Biological Materials, Biological Materials - Receptors/Targets, Research Tools, Research Tools - Screening
Category(s): Biological Materials, Research Tools
D2 Dopamine Receptor Knock-Out Mice
Technology OverviewD2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice, technology #...
Published: 4/28/2010   |   Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein, Michele Kelly
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
D4 Dopamine Receptor Knock-Out Mice
Technology OverviewResearchers at OHSU have developed technology # 0379, a strain of mice that are genetically deficient in the D4 dopamine receptor. These mice provide a new animal model for the study of the function of the D4 receptor. Homozygous mice may exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine, as well...
Published: 4/28/2010   |   Inventor(s): Malcolm Low, David Grandy, Marcelo Rubinstein
Keywords(s): Biological Materials, Biological Materials - Mice, Research Tools, Research Tools - Screening
Category(s): Biological Materials
A Novel Human Dopamine Receptor and its Uses (D4 subtypes - D4.2,4.4,4.7)
Technology OverviewTechnology 0250 is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and allelic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constru...
Published: 4/28/2010   |   Inventor(s): Olivier Civelli, Hubert Henri-Marie Van Tol, James Bunzow, David Grandy
Keywords(s): Biological Materials, Biological Materials - Receptors/Targets, Research Tools, Research Tools - Screening
Category(s): Research Tools
D2 Dopamine Receptor and Genes and Associated United States Patents
Technology Overview Researchers at OHSU have cloned the D2 Dopamine receptor, and have developed cell lines containing both the D2 short and long forms, which are useful in studying ligand-receptor interactions, and developing potential drug candidates for treatment of neurological diseases. Currently, the university holds numerous patents co...
Published: 4/28/2010   |   Inventor(s): Olivier Civelli, James Bunzow, David Grandy, Curtis Machida
Keywords(s): Biological Materials, Biological Materials - Receptors/Targets, Research Tools, Research Tools - Screening
Category(s): Research Tools
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